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One-carbon nitrogen ring bases (thymine and cytosine) covalently linked to a sugar (ribose or deoxyribose) and one to three phosphate groups; can function as extracellular messengers, antimetabolites, and chain terminators that inhibit viral DNA polymerase.
Glucosamine sulfate (CAS No 29031-19-4) is a naturally occurring compound primarily used in the biomedical research category of osteoarthritis and joint health Originating from the chitin of shellfish it functions by influencing the synthesis of glycosaminoglycans which are critical for maintaining cartilage structure The mechanism of action involves modulation of inflammatory pathways including inhibition of cartilage-degrading enzymes and the reduction of inflammatory cytokines Common in vitro activity is observed in the low micromolar range reflecting its potency in these biological systems Glucosamine sulfate is frequently applied in cell models and animal studies to assess its therapeutic potential in joint and cartilage health often serving as a candidate in drug screening for anti-inflammatory and chondroprotective agents Experimental concentrations typically depend on the specific research design ensuring optimal relevance and translatability of the findings
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Uridine (CAS 58-96-8) is a nucleoside that serves as a critical biochemical precursor for RNA synthesis through enzymatic polymerization pathways As a pyrimidine nucleoside uridine participates directly in nucleotide metabolism impacting cellular energy processes and nucleotide balance Additionally uridine demonstrates vasodilatory properties exerting effects on vascular tone through mechanisms likely involving purinergic signaling pathways It can also modulate contractility in specific tissue models Due to these characteristics uridine is extensively utilized in biomedical research focusing on RNA metabolism vascular biology and muscle contraction dynamics
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D-Glucosamine 6-phosphate is an endogenous metabolite that can be synthesized by glutamine fructose-6-phosphate amidotransferase (GFAT). It can be used for the research of diabetes mellitus.
Purity: 99.97%
Appearance: Solid
Color: White to off-white
Initial source: Endogenous metabolite, human gut microbiota metabolites
Solubility (in vitro): H2O: 125 mg/mL (482.35 mM; need ultrasonic)
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Uridine-13C5 (β-Uridine-13C5) is a 13C labeled Uridine (HY-B1449). Uridine (β-Uridine) is a nucleoside compound consisting of uracil and a ribose ring, which are linked by a β-N1- glycosyl bond.
This compound can be used as a tracer.
This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
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UDP-GlcNAz disodium is an analogue of UDP-GlcNAc disodium. It functions as a donor substrate for various N-acetylgalactosaminyltransferases and is a click chemistry reagent with an Azide group, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions.
Functions as a sugar donor
Serves as a substrate for OGTase and O-GlcNAcase
Capable of glycosylating p62
Glycosidic bond can be cleaved by O-GlcNAcase catalysis
Useful in research concerning protein glycosylation
Can be incorporated into nuclear proteins in Jurkat cells
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Uridine diphosphate (UDP)-GalNAc acts as a precursor in the biosynthesis of O-linked oligosaccharide. It also acts as a substrate for synthesis of chitin a vital element of cell walls in fungi and of exoskeletons of arthropods and insects.
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Uridine diphosphate (UDP)-GalNAc acts as a precursor in the biosynthesis of O-linked oligosaccharide. It also acts as a substrate for synthesis of chitin a vital element of cell walls in fungi and of exoskeletons of arthropods and insects.
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UDP-GlcNAc disodium salt is the disodium salt of uridine diphosphate N-acetylglucosamine, an activated nucleotide sugar used as the donor substrate for O-GlcNAc transferase (OGT) in enzymatic glycosylation studies. It is supplied as a white to off-white solid with high purity and is intended for biochemical and enzymology research.
Donor substrate for O-GlcNAc transferase-mediated protein O-GlcNAcylation.
High purity (99.9%) suitable for analytical and enzymatic assays.
Supplied as a stable solid for long-term storage at -20°C.
Soluble in aqueous buffers for in vitro reaction use.
Available in multiple small-scale sizes for research convenience.
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UDP-GlcNAc disodium salt (UDP-α-D-N-Acetylglucosamine disodium salt) is a donor substrate of O-GlcNAc transferase (OGT). OGT is a nucleocytoplasmic glycosyltransferase assigned to the GT41 family. This enzyme modifies thousands of proteins by adding a unique N-acetylglucosamine residue onto acceptor substrates mainly confined within the cytosol and nucleus.
Target: OGT
Pathway: Neuronal signaling
Storage: -20°C, sealed, away from moisture; unstable in solutions
Solubility (in vitro): H2O: 125 mg/mL
Molecular formula: C17H25N3Na2O17P2
Appearance: Solid
Color: White to off-white
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